Gene information
Official symbol CR1
Official full name complement C3b/C4b receptor 1 (Knops blood group)
Gene type protein-coding gene
Chromosome1q32.2
Alias symbolCD35; KN
Gene familyBlood group antigens; CD molecules; Sushi domain containing; Complement system regulators and receptors
Resources
Entrez Gene 1378
HGNC HGNC:2334
Ensembl ENSG00000203710
Vega OTTHUMG00000036311
UCSC uc001hfx.4
GO terms: 110 records
GO Description Category LogP Number of genes Detail
GO:0001618 virus receptor activity GO Molecular Functions -7.88412825 17 More
GO:0001818 negative regulation of cytokine production GO Biological Processes -48.9957481 97 More
GO:0001846 opsonin binding GO Molecular Functions -7.66060590 6 More
GO:0001848 complement binding GO Molecular Functions -6.79568546 6 More
GO:0002250 adaptive immune response GO Biological Processes -8.22919489 29 More
GO:0002252 immune effector process GO Biological Processes -24.2648770 43 More
GO:0002253 activation of immune response GO Biological Processes -3.86084748 14 More
GO:0002443 leukocyte mediated immunity GO Biological Processes -15.2263375 27 More
GO:0002449 lymphocyte mediated immunity GO Biological Processes -8.72662877 18 More
GO:0002455 humoral immune response mediated by circulating immunoglobulin GO Biological Processes -5.71650362 10 More
GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO Biological Processes -11.9339394 22 More
GO:0002637 regulation of immunoglobulin production GO Biological Processes -8.47662495 11 More
GO:0002683 negative regulation of immune system process GO Biological Processes -26.6415063 77 More
GO:0002694 regulation of leukocyte activation GO Biological Processes -32.0887020 60 More
GO:0002695 negative regulation of leukocyte activation GO Biological Processes -9.84552767 31 More
GO:0002696 positive regulation of leukocyte activation GO Biological Processes -27.9249645 47 More
GO:0002697 regulation of immune effector process GO Biological Processes -33.2683521 48 More
GO:0002698 negative regulation of immune effector process GO Biological Processes -11.7829906 16 More
GO:0002699 positive regulation of immune effector process GO Biological Processes -18.3926498 29 More
GO:0002700 regulation of production of molecular mediator of immune response GO Biological Processes -19.7615296 26 More
GO:0002701 negative regulation of production of molecular mediator of immune response GO Biological Processes -8.92314992 9 More
GO:0002706 regulation of lymphocyte mediated immunity GO Biological Processes -13.7265777 21 More
GO:0002819 regulation of adaptive immune response GO Biological Processes -16.0189388 24 More
GO:0002822 regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO Biological Processes -14.6775052 22 More
GO:0002831 regulation of response to biotic stimulus GO Biological Processes -10.931136 25 More
GO:0002832 negative regulation of response to biotic stimulus GO Biological Processes -3.02904053 13 More
GO:0002920 regulation of humoral immune response GO Biological Processes -5.73581155 7 More
GO:0002922 positive regulation of humoral immune response GO Biological Processes -6.27426612 6 More
GO:0006956 complement activation GO Biological Processes -7.12107226 12 More
GO:0006958 complement activation, classical pathway GO Biological Processes -5.86439052 10 More
GO:0006959 humoral immune response GO Biological Processes -20.5068158 33 More
GO:0007009 plasma membrane organization GO Biological Processes -3.91866373 17 More
GO:0007162 negative regulation of cell adhesion GO Biological Processes -21.5212108 58 More
GO:0008285 negative regulation of cell population proliferation GO Biological Processes -53.5569125 147 More
GO:0010466 negative regulation of peptidase activity GO Biological Processes -24.1438543 35 More
GO:0010950 positive regulation of endopeptidase activity GO Biological Processes -13.2452311 34 More
GO:0010951 negative regulation of endopeptidase activity GO Biological Processes -24.7873219 35 More
GO:0010952 positive regulation of peptidase activity GO Biological Processes -14.1524623 37 More
GO:0016032 viral process GO Biological Processes -8.84449931 34 More
GO:0016064 immunoglobulin mediated immune response GO Biological Processes -6.28897630 13 More
GO:0019058 viral life cycle GO Biological Processes -10.6409496 31 More
GO:0019724 B cell mediated immunity GO Biological Processes -7.00231964 14 More
GO:0022407 regulation of cell-cell adhesion GO Biological Processes -32.4337382 53 More
GO:0022408 negative regulation of cell-cell adhesion GO Biological Processes -15.9068791 40 More
GO:0022409 positive regulation of cell-cell adhesion GO Biological Processes -25.7751074 39 More
GO:0030155 regulation of cell adhesion GO Biological Processes -41.8400792 131 More
GO:0030162 regulation of proteolysis GO Biological Processes -41.2267045 73 More
GO:0030449 regulation of complement activation GO Biological Processes -3.83961894 4 More
GO:0030667 secretory granule membrane GO Cellular Components -8.32957622 38 More
GO:0031347 regulation of defense response GO Biological Processes -64.5971043 148 More
GO:0031348 negative regulation of defense response GO Biological Processes -30.3795513 65 More
GO:0032102 negative regulation of response to external stimulus GO Biological Processes -54.2675416 110 More
GO:0032649 regulation of interferon-gamma production GO Biological Processes -12.4733429 27 More
GO:0032689 negative regulation of interferon-gamma production GO Biological Processes -6.05054543 11 More
GO:0032944 regulation of mononuclear cell proliferation GO Biological Processes -24.6915018 34 More
GO:0032945 negative regulation of mononuclear cell proliferation GO Biological Processes -3.06905273 11 More
GO:0042129 regulation of T cell proliferation GO Biological Processes -18.0871480 25 More
GO:0042130 negative regulation of T cell proliferation GO Biological Processes -2.70311986 5 More
GO:0043086 negative regulation of catalytic activity GO Biological Processes -41.1437610 130 More
GO:0044000 movement in host GO Biological Processes -9.40214314 25 More
GO:0044403 biological process involved in symbiotic interaction GO Biological Processes -18.5885778 29 More
GO:0044853 plasma membrane raft GO Cellular Components -18.4542052 33 More
GO:0045088 regulation of innate immune response GO Biological Processes -6.98001665 16 More
GO:0045121 membrane raft GO Cellular Components -30.0775030 71 More
GO:0045577 regulation of B cell differentiation GO Biological Processes -3.16367145 4 More
GO:0045580 regulation of T cell differentiation GO Biological Processes -7.18541630 25 More
GO:0045596 negative regulation of cell differentiation GO Biological Processes -26.9785067 101 More
GO:0045619 regulation of lymphocyte differentiation GO Biological Processes -8.78322888 17 More
GO:0045620 negative regulation of lymphocyte differentiation GO Biological Processes -5.62617381 12 More
GO:0045621 positive regulation of lymphocyte differentiation GO Biological Processes -6.96534841 12 More
GO:0045785 positive regulation of cell adhesion GO Biological Processes -29.6368249 50 More
GO:0045824 negative regulation of innate immune response GO Biological Processes -2.94039732 10 More
GO:0045861 negative regulation of proteolysis GO Biological Processes -27.9905009 43 More
GO:0045862 positive regulation of proteolysis GO Biological Processes -17.3242033 33 More
GO:0045917 positive regulation of complement activation GO Biological Processes -4.12631862 3 More
GO:0050670 regulation of lymphocyte proliferation GO Biological Processes -22.6006415 32 More
GO:0050672 negative regulation of lymphocyte proliferation GO Biological Processes -2.56497893 10 More
GO:0050777 negative regulation of immune response GO Biological Processes -11.1440698 32 More
GO:0050778 positive regulation of immune response GO Biological Processes -17.2528761 40 More
GO:0050863 regulation of T cell activation GO Biological Processes -20.3209154 36 More
GO:0050864 regulation of B cell activation GO Biological Processes -7.98662389 16 More
GO:0050865 regulation of cell activation GO Biological Processes -40.6877761 71 More
GO:0050866 negative regulation of cell activation GO Biological Processes -13.9027363 39 More
GO:0050867 positive regulation of cell activation GO Biological Processes -31.2431659 51 More
GO:0050870 positive regulation of T cell activation GO Biological Processes -17.6497748 28 More
GO:0051249 regulation of lymphocyte activation GO Biological Processes -22.6120519 46 More
GO:0051250 negative regulation of lymphocyte activation GO Biological Processes -7.76846228 25 More
GO:0051251 positive regulation of lymphocyte activation GO Biological Processes -20.2181987 37 More
GO:0051345 positive regulation of hydrolase activity GO Biological Processes -19.7369783 79 More
GO:0051346 negative regulation of hydrolase activity GO Biological Processes -26.0030636 42 More
GO:0051701 biological process involved in interaction with host GO Biological Processes -10.6054189 28 More
GO:0052547 regulation of peptidase activity GO Biological Processes -35.5643317 55 More
GO:0052548 regulation of endopeptidase activity GO Biological Processes -34.9486589 53 More
GO:0070663 regulation of leukocyte proliferation GO Biological Processes -26.8242532 37 More
GO:0070664 negative regulation of leukocyte proliferation GO Biological Processes -3.96184640 13 More
GO:0070820 tertiary granule GO Cellular Components -12.1965297 19 More
GO:0098857 membrane microdomain GO Cellular Components -30.8181788 72 More
GO:0101002 ficolin-1-rich granule GO Cellular Components -6.76434995 14 More
GO:0101003 ficolin-1-rich granule membrane GO Cellular Components -1.86130079 7 More
GO:0140272 exogenous protein binding GO Molecular Functions -8.63789613 18 More
GO:0140375 immune receptor activity GO Molecular Functions -8.53513203 25 More
GO:1902105 regulation of leukocyte differentiation GO Biological Processes -18.8286876 32 More
GO:1902106 negative regulation of leukocyte differentiation GO Biological Processes -7.27922558 19 More
GO:1902107 positive regulation of leukocyte differentiation GO Biological Processes -14.6775052 22 More
GO:1903037 regulation of leukocyte cell-cell adhesion GO Biological Processes -23.2079690 66 More
GO:1903038 negative regulation of leukocyte cell-cell adhesion GO Biological Processes -10.2281373 27 More
GO:1903039 positive regulation of leukocyte cell-cell adhesion GO Biological Processes -20.7355312 32 More
GO:1903706 regulation of hemopoiesis GO Biological Processes -16.2759166 33 More
GO:1903707 negative regulation of hemopoiesis GO Biological Processes -7.72888419 20 More
GO:1903708 positive regulation of hemopoiesis GO Biological Processes -14.6775052 22 More
KEGG pathways: 5 records
KEGG Description Category LogP Number of genes Detail
hsa04610 Complement and coagulation cascades KEGG Pathway -50.1154932 39 More
hsa04640 Hematopoietic cell lineage KEGG Pathway -11.4657972 15 More
hsa05134 Legionellosis KEGG Pathway -13.8022551 14 More
hsa05144 Malaria KEGG Pathway -31.5561809 24 More
hsa05152 Tuberculosis KEGG Pathway -14.5221547 22 More
Drug-Gene interaction
view
Related drugs: 2 records
Drug name Interaction type Source PMID View
cdx-1135 TTD view
eculizumab PharmGKB 24038027 view
Related studies: 2 records
Molecular factor Omics type Application Objective MI type Reference
complement receptor type 1 proteomics acute ST elevation myocardial infarction[diagnosis] acute ST elevation myocardial infarction Karthikeyan G et al. J Thromb Thrombolysis. 2007
complement receptor type 1 proteomics adverse events[prognosis (bad)] acute ST elevation myocardial infarction Karthikeyan G et al. J Thromb Thrombolysis. 2007
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